BGC > Product Search > AG 126 | 118409-62-4

Molecular Formula: C10H5N3O3
Molecular Weight: 215.16
Hazard Symbols: T
WGKGermany: 3

Description :
Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM . AG 126 may represent a new approach for the therapy of inflammation.

• Molecular Weight :215.16
• Purity :95%

Molecular Formula :
C10H5N3O3
Canonical SMILES :
C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
InChI :
InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChIKey :
DUQADSPERJRQBW-UHFFFAOYSA-N
Solubility :
Soluble in DMSO
Appearance :
Crystalline Solid
Application :
anti- inflammation
Storage : -20°C Freezer
Synonyms :
AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

More details are to be found here

Description :
Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM . AG 126 may represent a new approach for the therapy of inflammation.

• Molecular Weight :215.16
• Purity :95%

Molecular Formula :
C10H5N3O3
Canonical SMILES :
C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
InChI :
InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChIKey :
DUQADSPERJRQBW-UHFFFAOYSA-N
Solubility :
Soluble in DMSO
Appearance :
Crystalline Solid
Application :
anti- inflammation
Storage : -20°C Freezer
Synonyms :
AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

More details are to be found here